Ann Dermatol.  2011 Oct;23(Suppl 2):S250-S253. 10.5021/ad.2011.23.S2.S250.

A Case of Sinusoidal Hemangioma with Lipoma

• Song BH
• Youn SH
• Park EJ
• Kwon IH
• Kim KH
• Kim KJ

• KMID: 2156802
• DOI: http://doi.org/10.5021/ad.2011.23.S2.S250

Abstract

Sinusoidal hemangioma is a distinctive subset of a group of lesions known collectively as cavernous hemangiomas. Clinically, it develops in adults, predominantly females, and presents as a solitary, painless, bluish, deep dermal or subcutaneous nodule. Lipoma is the most common benign soft tissue tumor. Lipoma is distinguished from sinusoidal hemangioma on both clinical and histological grounds. Several studies have suggested that adipocytes originate from perivascular cells during adipogenesis. Angiogenic cytokines released by adipocytes play a role in the vasoproliferative response. The rearrangement or loss of chromosome 13 can also be associated with hemangioma. However, no previous cases of sinusoidal hemangioma have been associated with benign tumors like lipoma. Here, we describe an unusual case of sinusoidal hemangioma that occurred together with a lipoma on the right upper arm of a 43-year-old male.

Keyword

Angiogenic cytokine; Chromosome 13; Lipoma; Sinusoidal hemangioma

MeSH Terms

Adipocytes
Adipogenesis
Adult
Arm
Chromosomes, Human, Pair 13
Cytokines
Female
Hemangioma
Hemangioma, Cavernous
Humans
Lipoma
Male
Cytokines

Figure

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  Fig. 1 A solitary, relatively well-defined, pea-sized, bluish subcutaneous nodule on the right upper arm.

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  Fig. 2 On the upper left side of the picture, is a well-circumscribed, lobulated mass in the subcutaneous tissue. The mass is not encapsulated, and is composed of dilated and interconnecting vascular channels forming a sinusoidal structure. In the lower right region of the mass, is a well-circumscribed collection of benign mature adipocytes surrounded by a fibrous capsule (H&E, ×20).

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  Fig. 3 Dilated vessels, with pseudopapillae and many red blood cells in the lumen, show a back-to-back arrangement (H&E, ×200).

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  Fig. 4 In the lower right region of the hemangioma is, a benign tumor consisting of mature signet-ring fat cells (H&E, ×100).

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