Ann Dermatol.  2011 Sep;23(Suppl 1):S16-S19. 10.5021/ad.2011.23.S1.S16.

A Case of Benign Cephalic Histiocytosis

• Kim BC
• Choi WJ
• Seung NR
• Park EJ
• Cho HJ
• Kim KH
• Kim KJ

• KMID: 2156742
• DOI: http://doi.org/10.5021/ad.2011.23.S1.S16

Abstract

Benign cephalic histiocytosis (BCH) is a rare non-Langerhans cell histiocytosis of unknown etiology. Clinically, lesions are characterized by small, red-to-yellow papules distributed mainly on the head, face, neck, and shoulders of infants and children. Histopathological specimens show massive histiocytic infiltration of the superficial dermis. Immunohistochemically, they are positive for CD68, but negative for CD1a and S-100. Two cases have been reported so far in the relevant work published in Korean literature. Herein, we report on an additional case of BCH.

Keyword

Histiocytosis; Non-Langerhans-Cell

MeSH Terms

Child
Dermis
Head
Histiocytosis
Humans
Infant
Neck
Shoulder

Figure

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  Fig. 1 Erythematous grouped papules on wheal-like plaques on the right cheek.

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  Fig. 2 (A) Diffuse cell infiltrates were observed throughout the dermis (H&E, ×100). (B) High power view demonstrating proliferation of large, epithelioid histiocytic cells with eosinophilic cytoplasm (H&E, ×400).

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  Fig. 3 Immunohistochemical staining shows (A) positive for CD68 (×400), negative for (B) S-100 and (C) CD1a (×400).

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