Exp Mol Med.
2015 Mar;47(3):e150. 10.1038/emm.2014.122.
The role of mitochondrial DNA mutation on neurodegenerative diseases
- Affiliations
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- 1Department of Biochemistry and Biomedical Sciences, Seoul National University, College of Medicine, Seoul, Korea. inhee@snu.ac.kr
- KMID: 2155415
- DOI: http://doi.org/10.1038/emm.2014.122
Abstract
- Many researchers have reported that oxidative damage to mitochondrial DNA (mtDNA) is increased in several age-related disorders. Damage to mitochondrial constituents and mtDNA can generate additional mitochondrial dysfunction that may result in greater reactive oxygen species production, triggering a circular chain of events. However, the mechanisms underlying this vicious cycle have yet to be fully investigated. In this review, we summarize the relationship of oxidative stress-induced mitochondrial dysfunction with mtDNA mutation in neurodegenerative disorders.
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