Korean J Pediatr.  2016 Jan;59(1):24-29. 10.3345/kjp.2016.59.1.24.

Factors associated with mumps meningitis and the possible impact of vaccination

Affiliations
  • 1Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea. polo96@daum.net
  • 2Department of Neurology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
  • 3Gyeongsang Institute of Health Science, Jinju, Korea.

Abstract

PURPOSE
Mumps meningitis is a common complication of mumps infection; however, information on mumps meningitis in the postvaccine era is limited. The purpose of the present study was to determine factors associated with mumps meningitis and to discuss the effect of vaccination on this disease.
METHODS
We retrospectively reviewed patients younger than 19 years with mumps, diagnosed at a university hospital in Korea between 2003 and 2013. Patients were divided into groups with and without meningitis, and the clinical features of the 2 groups were compared.
RESULTS
The study enrolled 119 patients: 19 patients with meningitis and 100 patients without. Univariate analysis showed that older age (median: 15 years vs. 9.5 years, respectively), a longer interval from last vaccination (median: 10.2 years vs. 4.8 years, respectively), and febrile presentation (94.7% vs. 31.0%, respectively) were significantly associated with mumps meningitis. Sex, number of vaccination doses, bilateral parotitis, and the presence of complications other than meningitis did not differ between the 2 groups. In multivariate logistic regression analysis, age (odds ratio, 1.38; 95% confidence interval, 1.01-1.89; P=0.04) and fever (odds ratio, 30.46; 95% confidence interval, 3.27-283.61; P<0.01) remained independent factors for mumps meningitis.
CONCLUSION
Clinicians in the postvaccine era should be aware of the possibility of mumps meningitis in febrile cases of mumps in adolescents, regardless of the number of vaccination doses. To establish the role of vaccination in mumps meningitis, further studies will be necessary.

Keyword

Mumps; Viral meningitis; Measles-mumps-rubella vaccine; Child

MeSH Terms

Adolescent
Child
Fever
Humans
Korea
Logistic Models
Measles-Mumps-Rubella Vaccine
Meningitis*
Meningitis, Viral
Mumps*
Parotitis
Retrospective Studies
Vaccination*
Measles-Mumps-Rubella Vaccine
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