Ewha Med J.  2016 Jan;39(1):17-22. 10.12771/emj.2016.39.1.17.

Isolated Myeloid Sarcoma Presenting as Cord Compression by Paraspinal Mass

Affiliations
  • 1Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. yjyuh@paik.ac.kr
  • 2Department of Pathology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
  • 3Department of Laboratory Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.

Abstract

Myeloid sarcoma is a rare tumor mass consisting of immature granulocytic cells occurring in an extramedullary site or in a bone. It has often been observed during the course of an acute leukemia, myelodysplastic syndrome or myeloproliferative neoplasms, and it can involve any site of the body. However, it rarely present in the absence of bone marrow infiltration, especially for the isolated spinal myeloid sarcoma. In this report, we describe a case of isolated myeloid sarcoma that showed spinal compression. A 66-year-old male, with no underlying disease or medication history, presented with a progressive back pain and numbness in bilateral lower extremities that had begun two weeks before. He was diagnosed with myeloid sarcoma with no evidence of bone marrow involvement. Tumor cells were positive for CD34, c-KIT, and Bcl-2 on the immunohistochemical stain. He was treated with systemic chemotherapy with daunorubicin plus cytosine arabinoside and achieved a partial response.

Keyword

Myeloid sarcoma; Spinal cord compression; Leukemia
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