J Pathol Transl Med.  2015 Jul;49(4):343-345. 10.4132/jptm.2015.04.27.

Late Bone Metastasis of Histologically Bland Struma Ovarii: The Unpredictability of Its Biologic Behavior

• Oh SJ
• Jung M
• Kim YO

• KMID: 2151146
• DOI: http://doi.org/10.4132/jptm.2015.04.27

Abstract

No abstract available.

MeSH Terms

Neoplasm Metastasis*
Struma Ovarii*

Figure

• 

  Fig. 1. (A) Sagittal magnetic resonance imaging showing an ill-defined lytic mass involving the thoracic 12 level. The mass destructs the vertebral body and spinal canal extending to the pedicle. (B, C) Needle biopsy of the spinal lesion reveals benign-looking thyroid follicles. (D) These cells are positive for thyroglobulin on immunohistochemical stain, supporting thyroid origin.

• 

  Fig. 2. Histological features of struma ovarii. Most of the tumor consist of dilated follicles reminiscent of nodular goiter (A) while a small part of the tumor shows densely packed microfollicles (B) with mild nuclear irregularity, overlapping, and vague clearing (C).

Reference

1. Kurman RJ, Carcangiu ML, Herrington CS, Young RH. WHO classification of tumours of female reproductive organs. 4th ed. Lyon: IARC Press;2014.

2. Roth LM, Karseladze AI. Highly differentiated follicular carcinoma arising from struma ovarii: a report of 3 cases, a review of the literature, and a reassessment of so-called peritoneal strumosis. Int J Gynecol Pathol. 2008; 27:213–22.

3. Karseladze AI, Kulinitch SI. Peritoneal strumosis. Pathol Res Pract. 1994; 190:1082–5.

4. Devaney K, Snyder R, Norris HJ, Tavassoli FA. Proliferative and histologically malignant struma ovarii: a clinicopathologic study of 54 cases. Int J Gynecol Pathol. 1993; 12:333–43.

5. Rosenblum NG, LiVolsi VA, Edmonds PR, Mikuta JJ. Malignant struma ovarii. Gynecol Oncol. 1989; 32:224–7.

6. Shaco-Levy R, Bean SM, Bentley RC, Robboy SJ. Natural history of biologically malignant struma ovarii: analysis of 27 cases with extraovarian spread. Int J Gynecol Pathol. 2010; 29:212–27.

7. Robboy SJ, Shaco-Levy R, Peng RY, et al. Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread. Int J Gynecol Pathol. 2009; 28:405–22.

8. Garg K, Soslow RA, Rivera M, Tuttle MR, Ghossein RA. Histologically bland “extremely well differentiated” thyroid carcinomas arising in struma ovarii can recur and metastasize. Int J Gynecol Pathol. 2009; 28:222–30.

9. Marti JL, Clark VE, Harper H, Chhieng DC, Sosa JA, Roman SA. Optimal surgical management of well-differentiated thyroid cancer arising in struma ovarii: a series of 4 patients and a review of 53 reported cases. Thyroid. 2012; 22:400–6.