Korean J Dermatol.  1987 Jun;25(3):404-409.

A Case of Juvenile Xanthogranuloma Associated with Juvenile Chronic Myeloid Leukemia and Neurofibromatosis

• Roh JY
• Park HJ
• Cinn YW
• Kim SN
• Kim SG

Abstract

Juvenile xanthogranuloma(JXG) is a a benign histiocytic proliferative disorder most frequently seen in infants. The usual course is self-limited, but it may be a manifestation of juvenile chronic myeloid leukemia(JCML). In addition to JXG, some patient with JCML may have multiple cafe-au-lait spots and a family history of neurofibromatosis(NF). The association of JXG and cafe-au-lait spots in patients with JCML is of interest in light of description of otherwise healthy children with JXG who also had cafe-au-lait spots. We report herein a case of JXG in 18-month-old boy who also had multiple cafe-au-alit spots, which predated the JCML.

Keyword

Juvenile xanthogranuloma; Juveile chronic myeloid leukemia; Neurofibro - matosis

MeSH Terms

Cafe-au-Lait Spots
Child
Humans
Infant
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
Male
Neurofibromatoses*
Xanthogranuloma, Juvenile*