Korean J Dermatol.  2002 Jan;40(1):112-114.

Four Cases of Atopic Dermatitis with Topical Tacrolimus Therapy

Affiliations
  • 1Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

Tacrolimus is a macrolide antibiotic that was isolated from soil microorganism. Its mechanism of action is based on calcineurin inhibition, which results in suppression of antigen-specific T-cell activation and inhibition of inflammatory cytokine release. Four patients with atopic dermatitis participated in this study of the efficacy of topical tacrolimus. Our cases showed significant improvement in the signs and symptoms of atopic dermatitis within a week of starting topical tacrolimus. We report 4 cases of atopic dermatitis treated with 0. 1% tacrolimus ointment.

Keyword

Atopic dermatitis; Tacrolimus

MeSH Terms

Calcineurin
Dermatitis, Atopic*
Humans
Soil
T-Lymphocytes
Tacrolimus*
Calcineurin
Soil
Tacrolimus
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