Korean Circ J.  1986 Mar;16(1):127-135. 10.4070/kcj.1986.16.1.127.

Beneficial Hemodynamic Response to Oral Prazosin Therapy in Severe Congestive Heart Failure

• Kim SG
• Park SJ
• Jeong MH
• Yoon YG
• Park JC
• Kang JC
• Park OK

• KMID: 2145756
• DOI: http://doi.org/10.4070/kcj.1986.16.1.127

Abstract

To evaluate the clinical and hemodynamic effects of prazosin therapy in severe congestive heart of various causes, 20 patients with severe CHF of NYHA functional class III or IV treated with oral prazosin were examined before and after the addition of parazosin. The assessment of the effects were done by clinical observation and with hemodynamic parameters measured from M-mode echocardiogram of the left ventricle. Ninety minutes after the first dose of 6mg, endsystolic dimensions were decreased significantly while stroke volume, ejection fraction, fractional shortening, mean rate of circumferential fiber shortening and stroke work were increased significantly. Left ventricular ejection time and cardiac output were not changed measurably with prazosin therapy. Seventeen out of 20 showed clinical improvement from NYHA functional class IV or III to III or II at the end of a week, majority of them reported improving their symptoms following the first dose of parazosin. We conclude that the oral parazison is safe and effective in the treatment of severe CHF of various causes.

MeSH Terms

Cardiac Output
Estrogens, Conjugated (USP)*
Heart
Heart Failure*
Heart Ventricles
Hemodynamics*
Humans
Prazosin*
Stroke
Stroke Volume
Estrogens, Conjugated (USP)
Prazosin