J Korean Soc Magn Reson Med.  2013 Dec;17(4):286-293. 10.13104/jksmrm.2013.17.4.286.

A Study of Changes of Inversion Time Effect on Brain Volume of Normal Volunteers

• Kim JH
• Kim SH
• Shin HS
• Kim JE
• Na JB
• Park K
• Choi DS

• KMID: 2144330
• DOI: http://doi.org/10.13104/jksmrm.2013.17.4.286

Abstract

PURPOSE
The objective of this study was to analyze the brain volume according to the brain image of healthy adults in the 20s taken with different inversion time (TI).
MATERIALS AND METHODS
Brain images of healthy adults in the 20 s were acquired using magnetization prepared rapid acquisition gradient echo (MPRAGE) pulse sequence with 1.5 mm thickness of pieces and four inversion times (1100 ms, 1000 ms, 900 ms, 800 ms). The acquired brain images were analyzed to measure the volume of white matter (WM), gray matter (GM), intracranial volume (ICV). The statistical difference according to brain volume and gender was analyzed for each TI.
RESULTS
The brain volume calculated using Freesurfer was WM=486.52+/-48.64 cm3 and GM=646.86+/-57.12 cm3 in mean when adjusted by mean ICV=1278.94+/-154.92 cm3. Men's brain volume(WM, GM, ICV) was larger than women's brain volume. In the intrarater reliability test, all of the intraclass correlation coefficients were high (0.992 for WM, 0.988 for GM, and 0.997 for ICV). In the repeated measures analysis of variance, GM and ICV did not show a significant difference at each TI (GM p=0.143, ICV p=0.052), but WM showed a significant (p=0.001). In the linear structure relation analysis, all of the Pearson correlation coefficients were high.
CONCLUSION
WM, GM, and ICV indicated high reliability and solid linear structure relations, but WM showed significant differences at each TI. The brain volume of healthy adults in the 20s could be used in comparison with that of patients for reference purposes and to predict the structural change of brain. It would be needed to conduct additional studies to examine the contract, SNR, and lesion detection ability according to variable TI.

Keyword

Freesurfer; Volumetry; Magnetic resonance Imaging (MRI); Inversion time

MeSH Terms

Adult
Brain*
Healthy Volunteers*
Humans

Figure

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  Fig. 1 The results of images from the 3D MRI using automatic segmentation software. Original image (a), brain mask image (b), that removed skull from the original image (c), white matter (d). (Numerical values are inversion time in milliseconds)

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  Fig. 2 The results of each subject is represented as mean volumes on the image acquisition conditions (white matter, gray matter, intracranial volume).

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  Fig. 3 Scatter plot matrix for correlation analysis of inversion times of brain volumes (white matter, gray matter, intracranial volume).

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