Korean J Endocr Surg.  2014 Sep;14(3):167-170. 10.0000/kjes.2014.14.3.167.

Synchronous Occurrence of Papillary, Follicular, and Medullary Carcinoma in the Same Thyroid Gland

Affiliations
  • 1Thyroid Cancer Center, Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. surghsc@yuhs.ac
  • 2Thyroid Cancer Center, Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Incidence of thyroid carcinoma has increased dramatically; however, simultaneous occurrence of different tumors in a single thyroid gland is rare and the embryologic or molecular explanations for such cases lack a solid basis. We report on a 67-year-old woman who underwent surgery for cytologically undetermined nodules in the bilateral thyroid glands. Postoperative pathology findings indicated synchronous occurrence of discrete papillary, follicular, and medullary thyroid carcinoma. She has remained disease-free after postoperative radioactive iodine therapy (130 mCi). This is the fifth report on the synchronous occurrence of different tumors in a single thyroid gland worldwide, and the first ever in Asia.

Keyword

Papillary thyroid carcinoma; Follicular thyroid carcinoma; Medullary thyroid carcinoma; Synchronous neoplasms

MeSH Terms

Adenocarcinoma, Follicular
Aged
Asia
Carcinoma, Medullary*
Female
Humans
Incidence
Iodine
Neoplasms, Multiple Primary
Pathology
Thyroid Gland*
Thyroid Neoplasms
Iodine
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