Korean J Pediatr Hematol Oncol.  2002 Apr;9(1):117-121.

An Isolated Relapse of Acute Lymphoblastic Leukemia as a Chest Wall Mass

• Lee JY
• Song DJ
• Woo CO
• Lee JH
• Lee KC

Abstract

Extramedullary relapse of childhood acute lymphoblastic leukemia (ALL) occurs most commonly in the central nervous system or in the testes. Isolated relapse on chest wall as a soft tissue mass is extremely rare in children with ALL. We experenced a 12-year-old girl who developed an isolated relapse on chest wall during the treatment for ALL. She had a pain and protruding mass on right anterior chest wall 6 months after the initial diagnosis of ALL. Imaging study revealed an 5 7 cm sized soft tissue mass on the right chest wall. Histopathologic examination revealed infiltrates composed of immature lymphoblasts with morphology identical with that of previous bone marrow aspiration. Studies on bone marrow and cerebrospinal fluid were negative for disease at this time. The patient was treated with 3,000 cGy of local irradiation in 10 fractions and systemic chemotherapy with ifosfamide and etoposide. The mass size decreased markedly, but she has been suffering from development of multiple mass in other site and recurrent pleural effusion.

Keyword

Extramedullary relapse; Acute lymphoblastic leukemia

MeSH Terms

Bone Marrow
Central Nervous System
Cerebrospinal Fluid
Child
Diagnosis
Drug Therapy
Etoposide
Female
Humans
Ifosfamide
Pleural Effusion
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Recurrence*
Testis
Thoracic Wall*
Thorax*
Etoposide
Ifosfamide