Gut Liver.  2011 Jun;5(2):210-216.

Distribution Characteristics of Hepatitis B Serological Markers in Hospitalized Children and Adolescents in Zhejiang, China between 2006 and 2010

• Chen X
• Shen Y
• Xiang W

Abstract

BACKGROUND/AIMS
To investigate serological patterns of hepatitis B based on electrochemiluminescent immunoassays and the distribution characteristics of these patterns in hospitalized children and adolescents in Zhejiang, China between 2006 and 2010.
METHODS
Five serological markers, including hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), antibody to hepatitis B surface antigen (anti-HBs), antibody to hepatitis B e antigen (anti-HBe), and antibody to hepatitis B c antigen (anti-HBc), were chosen as a routine panel to monitor hepatitis B virus (HBV) infection and vaccination efficacy. A total of 33,187 children (21,187 boys and 12,000 girls) were selected using the following exclusion criteria: a previous diagnosis of hepatitis, age >16 years or an address outside of Zhejiang.
RESULTS
The average HBV vaccination coverage rates among 20,766 boys and 11,782 girls were 98.62% and 98.68%, respectively. Seventeen serological patterns of hepatitis B were found, and the dominant pattern was 'anti-HBs (+) alone' (62.03%) followed by 'negative pattern' (23.46%). The rates of the other 15 patterns ranged from 8.14% to 0.003%. Of 236 HBsAg-positive patients, the overall rate of seropositivity was 0.71%. The anti-HBs levels were grouped into 3 ranges (10-100 mIU/mL, 100-1,000 mIU/mL, and >1,000 mIU/mL) for all anti-HBs-positive children (36.08%, 43.43%, and 20.49%, respectively).
CONCLUSIONS
A low HBsAg carrier rate and a relatively high anti-HBs positive rate are present in hospitalized children and adolescents in Zhejiang. The distribution of serological patterns is associated with age but is mostly independent of gender.

Keyword

Hepatitis B antibodies; Chemiluminescent measurements; Immunoassay; Epidemiologic studies; Children

MeSH Terms

Adolescent
Child
Child, Hospitalized
China
Epidemiologic Studies
Hepatitis
Hepatitis B
Hepatitis B Antibodies
Hepatitis B Surface Antigens
Hepatitis B virus
Humans
Immunoassay
Luminescent Measurements
Organothiophosphorus Compounds
Vaccination
Hepatitis B Antibodies
Hepatitis B Surface Antigens
Organothiophosphorus Compounds