J Korean Ophthalmol Soc.  2004 Oct;45(10):1708-1712.

Influence of Botulinum Toxin A on Corneal Astigmatism

• Song YS
• Moon NJ

Abstract

PURPOSE
This study was conducted to determine if there is a corneal astigmatic change in patients with strong lid tension, such as essential blepharospasm. METHODS: Twenty-two eyes of 14 patients with blepharospasm who had undergone botulinum toxin A (Botox(R), Allergan) injection during the period February 2001 through January 2002 were included. The corneal astigmatic change was evaluated before injection and after 1st month and 6th month of injection by keratometric measurements. Corneal astigmatism was measured before and 1month after botulinum toxin A injection and changes of corneal astigmatism were checked using vector methods (corneal astigmatism change vector). RESULTS: The with-the-rule astigmatism group showed decreased average corneal astigmatism while the against-the-rule group showed increased astigmatism at 1month after injection. The corneal astigmatic change vector showed significantly greater against-the-rule change (16 eyes) than with-the-rule change (6 eyes) at 1 month after injection. CONCLUSIONS: We found that the corneal astigmatism was influenced by botulinum toxin A injection in patients with essential blepharospasm who seemed to have strong lid tension. Therefore it was proved that the corneal astigmatism was influenced by lid tension.

Keyword

Botulinum toxin A; Corneal astigmatism; Lid tension

MeSH Terms

Astigmatism*
Blepharospasm
Botulinum Toxins*
Humans
Botulinum Toxins