J Korean Ophthalmol Soc.  2003 Jul;44(7):1700-1706.

The Effect of the Combined Therapy with Amniotic Membrane and Tissue Adhesive on Impending Corneal Perforation

• Kim WT
• Cho SH
• Kim JC
• Lee DH

Abstract

PURPOSE
To report cases of impending corneal perforation which were treated with a combined therapy of cyanoacrylate tissue adhesive and amniotic membrane transplantation. METHODS: Five patients with a corneal ulcer were referred for the management of progressive corneal melting to the Department of Ophthalmology, Ilsan Paik Hospital from March 2000 to August 2001. Surgery performed according to the ulcer depth. When corneal tissue destruction was deep, minced amniotic membrane, tissue adhesive and amniotic membrane transplantation were applied, and, only tissue adhesive and amniotic membrane transplantation were done when not so deep. RESULTS: Postoperative follow-up period ranged from 13 months to 28 months (mean 18 months) In all five cases, combined therapy preserved the ocular integrity and reduced the inflammation. There was no infection or ulcer recurrence. In one case, penetrating keratoplasty was performed at 3 months after combined therapy. No serious complication was observed in this patient. CONCLUSIONS: These methods successfully restored the integrity of eyes and made subsequent penetrating keratoplasty possible. We suggest this surgical method as a useful treatment for impending corneal perforations.

Keyword

Amniotic membrane transplantation; Corneal ulcer; Impending corneal perforation; Tissue adhesive

MeSH Terms

Amnion*
Corneal Perforation*
Corneal Ulcer
Cyanoacrylates
Follow-Up Studies
Freezing
Humans
Inflammation
Keratoplasty, Penetrating
Ophthalmology
Recurrence
Tissue Adhesives*
Ulcer
Cyanoacrylates
Tissue Adhesives