J Korean Ophthalmol Soc.  2002 Nov;43(11):2258-2264.

The Effect of Basic Fibroblast Growth Factor on the Vascularization of Porous Polyethylene Orbital Implant(Medpor(R))

• Kim KR
• Jung CS
• Chung SK

Abstract

PURPOSE: We investigated the effect of basic fibroblast growth factor (bFGF) on the vascularization rate of Medpor(R), a synthetic polyethylene orbital implant.
METHODS
Medpor(R), pretreated or untreated with bFGF (25 ng/ml), was inserted into one eye of 18 New Zealand white rabbits and removed at 1, 2, and 4 weeks after implantation, and stained with hematoxylineosin and Masson's trichrome. Degree of vascularization was classified into zone 1 (or=4.6 mm ingrowth).
RESULTS
One and two weeks after implantation, the percentage of the vascularization area were 56.25% and 68.75% in bFGF-untreated group, while those of bGFG-treated group were 75% and 80.56% respectively, but there were no statistical difference between bFGF-untreated and treated group. However, four weeks after implantation it was significantly higher in bFGF-treated group (84.38%) than in bFGFuntreated group (66.25%) (P<0.05).
CONCLUSIONS
BFGF enhanced more and early fibrovascular ingrowth of Medpor(R).

Keyword

Basic fibroblast growth factor; Medpor(R); Vascularization

MeSH Terms

Fibroblast Growth Factor 2*
Orbit*
Orbital Implants
Polyethylene*
Rabbits
Fibroblast Growth Factor 2
Polyethylene