J Korean Ophthalmol Soc.  1993 Jul;34(7):606-612.

Co-cultivation of Adenovirus with Cultivated Conjunctival Epithelial Cell: Morphological Changes in Infected Cell

Affiliations
  • 1Department of Ophthalmology, School of Medicine Hanyang University, Seoul, Korea.

Abstract

This study was performed to investigate the morphological changes of the human conjunctival epithelium when the cultured conjunctival tissue was co-cultivated with the inoculated adenovirus. Specimens swabbed from the lower conjunctival sac of patients with epidemic Keratoconjunctivitis were inoculated into the cultured conjunctival epithelial cells and co-cultivated. The adenovirus-infected cell revealed viral particles, crystalline arrays of adenovirus, paracrystalline inclusions and three types of inclusions within the nucleus. The cytoplasm did not show the specific pathologic changes. These results suggest that adenovirus can be co-cultured with conjunctival epthelial cell and the infected cell showes the typical morphological changes within the nucleus. This in-vitro co-cultivation of adenovirus with conjunctival epithelial cell may be used for an in-vitro model in the research of adenovirus.

Keyword

Adenovirus; Epidemic keratoconjunctivitis; Inclusion body

MeSH Terms

Adenoviridae*
Crystallins
Cytoplasm
Epithelial Cells*
Epithelium
Humans
Inclusion Bodies
Keratoconjunctivitis
Virion
Crystallins
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