Korean J Urol.  1988 Aug;29(4):538-542.

Hypothalamic-Pituitary-Gonadal Function in Hepatic Failure, Clinical Study

• Kim YK
• Kim KM
• Kim SJ

Abstract

Hypothalamic-pituitary-gonadal function in male hepatic insufficiency was clinically in vestigated using cases of chronic hepatitis of viral origin, liver cirrhosis and non-hepatic control, with particular attention on incidencies of esophageal varix, spider angioma, palmar erythema and ascitic accumulation along with measurement of plasma levels of testosterone, estradiol, luteinizing hormone and follicle stimulating hormone. The following results were obtained : 1. Significant decreases of plasma testosterone and significant increase of estradiol were observed in cases of liver cirrhosis. The value of luteinizing hormone increased with significance. 2. Incidencies of esophageal varix, ascites, spider angioma and palmar erythema were higher in liver cirrhosis than in chronic hepatitis. 3. Decrease in testosterone level and increase of estradiol level were observed more prominently while there were higher grade of esophageal varix or presence of both spider angioma and palmar erythema throughout.

Keyword

hepatic failure; hypothalamus; pituitary; gonad

MeSH Terms

Ascites
Erythema
Esophageal and Gastric Varices
Estradiol
Follicle Stimulating Hormone
Gonads
Hemangioma
Hepatic Insufficiency
Hepatitis, Chronic
Humans
Hypothalamus
Liver Cirrhosis
Liver Failure*
Luteinizing Hormone
Male
Plasma
Spiders
Testosterone
Estradiol
Follicle Stimulating Hormone
Luteinizing Hormone
Testosterone