Lab Anim Res.  2010 Dec;26(4):433-438. 10.5625/lar.2010.26.4.433.

The Need for the Introduction of Assessment Program of Good Animal Care and Use Facility

• Lee SK
• Cha SW

• KMID: 2114714
• DOI: http://doi.org/10.5625/lar.2010.26.4.433

Abstract

The humane care and use of animals should be the prime concern and responsibility of all those individuals using animals for research, teaching or testing. The use of animals as experimental subjects in the 20th century has contributed to many important advances in scientific and medical knowledge. Although scientists have also developed non-animal models for research, these models often cannot completely mimic the complex human or animal body. Nevertheless, efforts to develop and use scientifically valid alternatives, adjuncts, and refinements to animal research should continue. Laboratory Animal Law that was prepared to improve the reliability and reproducibility of research data using laboratory animals also required an institutes to care and use animal in ways judged to be scientifically, technically, and humanely appropriate. The law introduced Assessment Program of Good Animal Care and Use Facility. The primary goal of the Assessment Program is to provide quality assurance for the care and use of experimental animals on a national basis. Although, an effective surveillance protects animals, promotes animal welfare and ensures the quality of science that uses animals, it is the responsibility of investigators to conduct animal experiment on the basis of the highest scientific, humane, and ethical principles. It is expected that the Program will accelerate the introduction of mind concerning humane and ethical animal experiment and will enhance animal well-being, the quality of biomedical research, and the advancement of biologic knowledge that is relevant to humans or animals.

Keyword

Laboratory animal law; facility assessment program; good animal care and use program

MeSH Terms

Academies and Institutes
Animal Experimentation
Animal Welfare
Animals
Animals, Laboratory
Humans
Hydrazines
Jurisprudence
Research Personnel
Hydrazines

Reference

References

Barnett, S.A. (. 1965. ). Adaptation of mice to cold. Biol. Rev. 40:5–51.

Barnett, S.A. (. 1973. ). Maternal processes in the cold-adaptation of mice. Biol. Rev. 48:477–508.

Barrett, A.M. and Stockham, M.A. (. 1963. ). The effect of housing conditions and simple experimental procedures upon the corticosterone level in the plasma of rats. J. Endocrinol. 26:97–105.

Borrow, P., Evans, C.F. and Oldstone, M.B. (. 1995. ). Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression. J. Virol. 69:1059–1070.

Broderson, J.R., Lindsev, J.R. and Crawford, J.E. (. 1976. ). The role of environmental ammonia in respiratory mycoplasmosis of rats. Am. J. Pathol. 85:115–130.

Brownstein, D.G. and Weir, E.C. (. 1987. ). Immunostimulation in mice infected with Sendai virus. Am. J. Vet. Res. 12:1692–1696.

Chvedoff, M., Clarke, M.R., Irisarri, E., Faccini, J.M. and Monro, A.M. (. 1980. ). Effects of housing conditions on food intake, body weight and spontaneous lesions in mice. A review of the literature and results of an 18-months study. Food Cosmet. Toxicol. 18:517–522.

Cockroft, A., Edwards, J., McCarthy, P. and Anderson, N. (. 1981. ). Allergy in laboratory animal workers. Lancet. 11:827–830.

Cray, C., Mateto, M.O. and Altman, N.H. (. 1993. ). In vitro and longterm in vivo immune dysfunction after infection of BALB/c mice with mouse hepatitis virus strain A59. Lab. Anim. Sci. 43:169–174.

Golberg, L. (. 1974. ). Carcinogenesis Testing of Chemicals. CRC Press, Cleveland. Han, J. (2008) Operation of ethical animal experiment. In Handbook of Ethical Animal Experiment, National Veterinary Research and Quarantine Service, Anyang. Harris, I. (1997). Variables in animal vased research: Part 1. Phenotypic variability in experimental animals. ANZCCART News. 10:1–7.

Iturrian, W.B. (. 1971. ). Effect of noise in the animal house on experimental seizures and growth of weaning mice. In Defining the Laboratory Animal, pp.332–352. IVth Symposium of the International Committee on Laboratory Animals, National Academy of Sciences, Washington.

Lee, Y.S. (. 1989. ). Laboratory Animal Medicine, pp. 16–41. Seoul National University Press, Seoul Manning.

P.J., Wagener, J.E. and Harkness. J.E. (. 1984. ). Biology and diseases of guinea pigs. In. Laboratory Animal Medicine. Fox , J.G. , editorsed.),. 2nd ed.p. 203–246. Academic Press, San Diego.

Modric, S., Webb, A.I. and Davidson, M. (. 1999. ). Effect of respiratory tract disease on pharmacokinetics of tilmicosin in rats. Lab. Anim. Sci. 49:248–253.

Nagasawa, H., Yamamoto, M., Fujimoto, M. and Kuretani, K. (. 1973. ). Effects of cage shape on mouse breeding and growth. Exp. Anim. 22:303–306.

Newton, W.M. (. 1978. ). Environmental impact on laboratory animals. Adv. Vet. Sci. Comp. Med. 22:1–28.

National Research Council. 1996. ). Guide for the Care and Use of Laboratory Animals, National Academy Press, Washington. Laboratory Animals, National Academy Press, Washington. Peterson, E.A. (1980) Noise in the animal environment. Lab. Anim. Sci. 30:422–439.

Pucak, G.J., Lee, C.S. and Zaino, A.S. (. 1977. ). Effects of prolonged high temperature on testicular development and fertility in the male rat. Lab. Anim. Sci. 27:76–77.

Reilly, J. (. 1998. ). Variables in animal based research: Part 2. Variability associated with experimental conditions and techniques. ANZCCART News. 11:1–12.

Schoeb, T.R., Davidson, M.K. and Lindsey, J.R. (. 1982. ). Intracage ammonia promotes growth of Mycoplasma pulmonis in the respiratory tract of rats. Infect. Immun. 38:212–217.

Ulberg, L.C. and Burfening, P.L. (. 1967. ). Embryo death resulting from adverse environment on spermatozoa or ova. J. Anim. Sci. 26:571–577.

Vesell, E.S., Lang, C.M., White, W.J., Passananti, C.T., Hill, R.N., Clemens, T.L., Lu, D.L. and Johnson, W.D. (. 1976. ). Environmental and genetic factors affecting response of laboratory animals to drugs. Fed. Proc. 35:1125–1132.

Winter, C.A. and Flataker, L. (. 1962. ). Cage design as a factor influencing acute toxicity of respiratory depressant drugs in rats. Toxic. Appl. Pharamcol. 4:650–655.

Yamaguchi C. (. 1995. ). Studies on the environmental control of laboratory animals. Exp. Anim. 44:9–21.

Yamaguchi, C., Fujita, S., Ohara, T. and Ueda, T. (. 1983. ). Effects of room temperature on reproduction, body and organ weights, food and water intakes, and hematology in mice. Exp. Anim. 32:1–11.

Yamauchi, C. (. 2008. ). Experimental Control of Laboratory Animals, pp. 1–6. Adthree, Tokyo.