J Korean Ophthalmol Soc.  2006 Sep;47(9):1410-1416.

Photodynamic Therapy Results of Retinal Angiomatous Proliferation with Pigmented Epithelial Detachment in Age-related Macular Degeneration

• Byeon SH
• Hong JP
• Lee H
• Oh SJ
• Kim SS
• Koh HJ
• Lee SC
• Kwon OW

Abstract

PURPOSE: To evaluate the incidence of retinal angiomatous proliferation (RAP) and retinal pigmented epithelial detachment (PED) in Korean age-related macular degeneration (ARMD) patients and results of photodynamic therapy (PDT) with verteporfin.
METHODS
Between May 2001 and December 2004, two hundred fifty-eight patients diagnosed of ARMD were evaluated and nine eyes of seven patients were as having RAP with PED. All patients underwent two or more sessions of PDT. Best-corrected visual acuity (BCVA), fundus photography, fluorescein angiography and ICG angiography were performed before and after treatment.
RESULTS
The incidence of RAP with PED was 2.8%. The mean age of onset was 71.7 and five of seven patients were female. After 17 months and mean 2.3 PDT treatments, mean BCVA decreased from 0.2 to 0.04. In two eyes, additional Transpupillary thermotherapy was undertaken. Occlusion of RAP and flattening of PED was observed in one eye, and four evolved toward stage 3 RAP. Three eyes with PDT developed tear of retinal pigmented epithelium.
CONCLUSIONS
Korean ARMD patients showed a low incidence of RAP and poor visual outcomes even with treatment.

Keyword

Age-related macular degeneration (ARMD); Photodynamic therapy (PDT); Pigmented epithelial detachment (PED); Retinal angiomatous proliferation (RAP); Visual outcome; Neovascularization

MeSH Terms

Age of Onset
Angiography
Epithelium
Female
Fluorescein Angiography
Humans
Hyperthermia, Induced
Incidence
Macular Degeneration*
Photochemotherapy*
Photography
Retinaldehyde*
Visual Acuity
Retinaldehyde