J Korean Ophthalmol Soc.  1993 Apr;34(4):321-326.

The Effect of 0.1% Topical Bunazosin(R) on the lOP of Normal Subjeets

• Ahn HB
• Yoo KW
• Rho SH

Abstract

The effects of topically applied bunazosin hydrochloride, Which has been developed as a highly selective alpha-1 adrenergic antagonist, on intraocular pressure(IOP), pupillary diameter, conjunctival injection, ptosis, and blood pressure were investigated in 14 normal volunteers. It is known that the mechanism of lOP reduction appears to be an increase in uveoscleral outflow and/or a decrease in episcleral venous pressure. The purpose of this experiment is to observe the effects of 0.1 % Bunazosin(R) on the lOP, pupil size, lid, conjunctival change and blood pressure in the normal human subject. The effects of 0.1% topical bunazosin(R) have been observed with placebo-controlled, double-blind single-dose study. The drug reduced lOP for 10 hours, and the decrease was statistically significant(p value <0.05). The lOP was decreased maximally at 3 hours after the instillation of the drug and the amount of the lOP reduction was 4.2mmHg. There were no significant changes of pupil size, lid configuration, conjunctival injection, and blood pressure in this experiment.

Keyword

alpha-1 antagonist; Bunazosin; lOP

MeSH Terms

Adrenergic Antagonists
Blood Pressure
Healthy Volunteers
Humans
Pupil
Venous Pressure
Adrenergic Antagonists