J Korean Ophthalmol Soc.  1992 Mar;33(3):238-247.

The Effect of Cytosine Arabinoside on Wound Healing after Glaucoma Filtering Surgery in the Rabbit

• Wee WR
• Youn DH

Abstract

Posterior lip sclerectomies were performed in rabbits and cytosine arabinoside (Ara-C) was applied by topical instillation or subconjunctival injection. In both groups, the mean intraocular pressure (lOP) of the treated eyes was significantly lower at postoperative week 1 and 2, but there was no significant difference between the mean lOP of the control eyes and that of the treated eyes at postoperative week 3 and 4. In both groups, at postoperative week 2, the sclerectomy sites of the control eyes were totally occluded by granulation tissue, but those of the treated eyes partially replaced by granulation tissue At postoperative week 4, the sclerectomy sites of the treated eyes were totally occluded by the granulation tissue ultimately in both groups. There were no differences in the mean lOP and the histologic finding of the treated eyes between the topical instillation group and the subconjuctival injection gorup. We concluded that either topical instillation or subconjunctival injection of Ara-C can delay wound healing at the surgical site after glaucoma filtering surgery in rabbits.

Keyword

Cytosine arabinoside; Glaucoma fitering surgery; Granulation tissue; Intraocular pressure

MeSH Terms

Cytarabine*
Cytosine*
Filtering Surgery*
Glaucoma*
Granulation Tissue
Intraocular Pressure
Lip
Rabbits
Wound Healing*
Wounds and Injuries*
Cytarabine
Cytosine