J Korean Ophthalmol Soc.  1993 Apr;34(4):311-320.

The Effects of Ascorbic Acid on Intraocular Pressure Elevation by Viscoelastic Substance

• Chung SK
• Baek NH

Abstract

We evaluated intraocular pressure(IOP), remained radioactivity of 51Cr tagged Healon(R) in the anterior chamber following lens aspiration in rabbit eyes, and ultrastructual changes of trabecular meshwork were observed after intravenous injection of ascorbic acid. The average lOPs returned to preoperative lOP level on the postoperative seventh day in control group. While, those in experimental group returned on the postoperative third day. Healon(R) was completely outflowed in control group on the postoperative seventh day and in experimental group, on the postoperative third day. There is a significant correlation between lOP and remained radioactivity rate of Healon(R) in control and experimental group. Under scanning electron microscope examination, the control group showed the most of Healon(R) debris outflowed on the postoperative seventh day. On the other hand, the experimental group showed no Healon(R) debris was observed on the postoperative third day. In conclusion, our experiment showed ascorbic acid is effective in lowering intraocular pressure and preventing chance of intraocular pressure elevation.

Keyword

Ascorbic acid; 51Cr tagged Healon(R); Intraocular pressure; Radioactivity; Trabecular meshwork

MeSH Terms

Anterior Chamber
Ascorbic Acid*
Hand
Injections, Intravenous
Intraocular Pressure*
Radioactivity
Trabecular Meshwork
Ascorbic Acid