J Korean Orthop Assoc.  2002 Feb;37(1):31-35.

Thrombotic and Fibrinolytic Abnormality in Nontraumatic Osteonecrosis of the Femoral Head

• Ha YC
• Koo KH
• Hwang SC
• Kim JR
• Park HB
• Kim SR
• Kim KM

Abstract

PURPOSE: This study was performed to determine whether abnormalities of thrombosis and fibrinolysis are associated with nontraumatic osteonecrosis of the femoral head.
MATERIALS AND METHODS
A case-control study was conducted in 24 patients with nontraumatic osteonecrosis of the femoral head. These patients were matched with 24 controls for gender, age (1-year range), and time of presentation (1-year range). The study included 19 men and 5 women, and the mean age of patients and controls was 46 years (range, 16-68 years). Eight patients had idiopathic osteonecrosis and the remaining 16 patients had secondary osteonecrosis. Protein C activity, protein C antigenicity, protein S activity, protein S antigenicity, antithrombin III, anticardiolipin antibody-Ig G, anticardiolipin antibody-Ig M, lupus anticoagulant, plasminogen, tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), and lipoprotein(a) were investigated.
RESULTS
Protein C antigenecity and protein S antigenecity, which have been known to decrease in osteonecrosis patients, were increased in patients compared with those of controls (P<0.05). No significant differences were found in the levels of other thrombotic or fibrinolytic factors. In a subgroup of 16 patients with secondary osteonecrosis, the level of anticardiolipin antibody immunoglobulin M was greater than in the respective controls (P<0.05).
CONCLUSION
The results of the current study suggest that abnormalities in the coagulation and fibrinolytic system are not associated with the pathogenesis of osteonecrosis of the femoral head.

Keyword

Femoral head; Osteonecrosis; Thrombophilia; Hypofibrinolysis

MeSH Terms

Antibodies, Anticardiolipin
Antithrombin III
Case-Control Studies
Female
Fibrinolysis
Head*
Humans
Immunoglobulin M
Lipoprotein(a)
Lupus Coagulation Inhibitor
Male
Osteonecrosis*
Plasminogen
Plasminogen Activators
Protein C
Protein S
Thrombophilia
Thrombosis
Tissue Plasminogen Activator
Antibodies, Anticardiolipin
Antithrombin III
Immunoglobulin M
Lipoprotein(a)
Lupus Coagulation Inhibitor
Plasminogen
Plasminogen Activators
Protein C
Protein S
Tissue Plasminogen Activator