J Korean Pain Soc.  1998 May;11(1):60-64.

A Comparison of Butorphanol and Fentanyl Administered in Conjuction with Ketorolac in Intravenous Patient Controlled Analgesia after Total Abdominal Hysterectomy

• Kim DH
• Min HR

Abstract

BACKGROUND: We compared butorphanol and fentanyl for opioids use in patient-controlled analgesia(PCA) with ketorolac to determine a suitable drug combination for postoperative pain control.
METHODS
Sixty patients were equally divided into 2 Groups. Group 1 (n-30) butorphanol 10 mg with ketorolac 180 mg; Group 2 (n 30) fentanyl 1 mg with ketorolac 180 mg, diluting 100 ml solutions intravenously via PCA pump after total abdominal hysterectomy under general anesthesia. Total infusion dosage of PCA drug, VAS pain scores, and side effects of both group were manitored.
RESULTS
Total infusion dosages were as follows: (Group 1) butorphanol 8.3 mg with ketorolac 149.7 mg; (Group 2) fentanyl 646.6 pg with ketorolac 116.2 mg. The two groups showed similar pain scores and side effects.
CONCLUSION
Both butorphanol and fentanyl were effective for postoperative pain control using PCA pump, but butorphanol was more economical. The putative potency ratio of butorphanol to fantanyl was 12.8 : 1.

Keyword

Analgesia, pain, patient-controlled, postoperative; Analgesics, butorphanol, fentanyl

MeSH Terms

Analgesia, Patient-Controlled*
Analgesics, Opioid
Anesthesia, General
Butorphanol*
Fentanyl*
Humans
Hysterectomy*
Ketorolac*
Pain, Postoperative
Passive Cutaneous Anaphylaxis
Analgesics, Opioid
Butorphanol
Fentanyl
Ketorolac