J Korean Pediatr Soc.  1993 Aug;36(8):1178-1182.

A case of agnogenic myeloid metaplasia

• Kim BJ
• Kim BY
• Min JS
• Seong H
• Choi CH

Abstract

Agnogenic myeloid metaplasia (AMM) is a myeloproliferative disorder characterized by leukoerythroblastosis, tear-drop erythrocytes, extramedullary hematopoiesis with hepatosplenomegaly, and varying degrees of myelofibrosis. The mean age at presentation is about 60 years, and pediatric cases are rare. We experienced a case of AMM in a 9 months old female who was presented with pallor, huge splenomegaly and intermittent fever. Peripheral blood showed leukoerythroblastosis poikilocytosis, and tear drop cells. Bone marrow was difficult to aspirate, and biopsy specimen showed increased reticulin with decreased cellularity, which was compatible with myelofibrosis. We presented a case of AMM with brief review of the literatures.

Keyword

Myelofibrosis; Myeloid metaplasia

MeSH Terms

Biopsy
Bone Marrow
Erythrocytes
Female
Fever
Hematopoiesis, Extramedullary
Humans
Infant
Myeloproliferative Disorders
Pallor
Primary Myelofibrosis*
Reticulin
Splenomegaly
Reticulin