Korean J Anesthesiol.  1987 Dec;20(6):756-761. 10.4097/kjae.1987.20.6.756.

Dose Related Neuromuscular Blocking Effects of Vecuronium Bromide in Rabbits

• Kim DW
• Min KH
• Kim KH
• Lee DH
• Kim KS
• Suh JK
• Yoo HK
• Seung IS
• Chon SU

• KMID: 2090492
• DOI: http://doi.org/10.4097/kjae.1987.20.6.756

Abstract

The introduction of muscle relaxants was an epoch-making event in the development of clinical anesthesia and their use has hecame essential to anesthesia practice. Vecuronium, one of the newest muscle relaxants, many advantages; it is .apid acting, non-accumulating, has minimals side reactions and is promptly antagonized by anticholinesterases. However, its pharmacological effect, like other conventional muscle relaxants depends upon the dose and is influenced br many factors including body temperature, blood flow, interaction with other drugs, antibiotics, diuretics and so forth, To obtain a dose-response relationship which is important for clinical use, the effect of the vecuronium in various doses on the neuromuscular block in rabbits was investigated. The results were as follows. 1) In the vecuronium 0.025 mg/kg group, maximal twitch depression was varied between 75 to 92% with a mean value of 84,9%. The spontaneous recovery index was 141.0 seconds (2.35 min). 2) In the vecuranium 7.75 mg/kg group, the mean maximum twitch depression and spontaneous recovery index were 98.4% and 218.6 seconds (3.64 min.) respectively. 3) In the vecuronium 7.1 mg/kg group, maximum twitch depression was 177% and the spontaneous recovery index was markedly prolonged to 627.8 seconds (10.35 min).

MeSH Terms

Anesthesia
Anti-Bacterial Agents
Body Temperature
Cholinesterase Inhibitors
Depression
Diuretics
Neuromuscular Blockade*
Rabbits*
Vecuronium Bromide*
Anti-Bacterial Agents
Cholinesterase Inhibitors
Diuretics
Vecuronium Bromide