Korean J Clin Pathol.  1997 Aug;17(4):553-559.

Diagnostic value of serum Troponin T measurements using EIA method in Acute Myocardial Infarction

• Kim YJ
• Kim DS
• Lee HS
• Choi SI

Abstract

BACKGROUND: Cardiac troponin T (cTnT) is a new serological marker for use as a diagnostic toots for acute myocardial infarction (AMI). This study was designed to evaluate tee diagnostic efficiency of troponin T in AMI.
METHODS
We determined the reference range of troponin T in 20 healthy adults without previous cardiovascular diseases and chest pain. We evaluated troponin-T, CK, LD, AST and CK-MB in serum of 13 AMI and 5 angina pectoris patients. The patients were arrived at the hospital within 3 hours after onset of (most recent) acute symptoms. Samples were drawn individually at the times of 0, 1, 3, 7, 18 and 24 hours after admission and continued at 6-h intervals for 2 days and 24-h intervals fort 2 weeks. Troponin T was determined by an enzyme-linked immuno-sorbent assay (one step sandwich assay) on an ES-300 analyzer.
RESULTS
We found that serum troponin-T concentrations in healthy control adults were below 0.07microgram/L. The peak level of troponin-T concentration of patients with AMI was 22.0microgram/L, mean value, at 7 hours after admission and showed 110 times its discrimination limit value (0.2microgram/L). CK-MB value was normalized within 3 days after admission, but cTnT value remained high above its discrimination limit value until 2 weeks after admission during this study.
CONCLUSIONS
The data indicate that the measurement of serum cTnT improves efficiency of serological testings of AMI as compared with conventionally used cardiac enzymes.

MeSH Terms

Adult
Angina Pectoris
Cardiovascular Diseases
Chest Pain
Discrimination (Psychology)
Humans
Myocardial Infarction*
Reference Values
Serologic Tests
Troponin T*
Troponin*
Troponin
Troponin T