Korean J Dermatol.
2010 Sep;48(9):786-789.
Embolia Cutis Medicamentosa Following Intramuscular Injection of Diclofenac
- Affiliations
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- 1Department of Dermatology, Kwandong University College of Medicine, Goyang, Korea. dermy@kd.ac.kr
- 2Department of Pathology, Kwandong University College of Medicine, Goyang, Korea.
Abstract
- Nicolau syndrome or embolia cutis medicamentosa is a rare complication of a still largely unidentified pathogenesis at the site of intramuscular injections of various drugs. It is characterized by development of an acute, severe pain around the injection site followed by a localized erythema, a reticular rash, a hemorrhagic patch and varying degrees of tissue damage. The disease outcomes vary from atrophic ulcers and pigmentation to lower limb paralysis and limb amputation. We describe a 34-year-old woman with the diagnosis of this syndrome after she received an intramuscular diclofenac-beta-dimethyl-aminoethanol injection to the lateral aspect of the right upper buttock. The patient was treated by surgical debridement with concomitant primary closure.
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