Korean J Dermatol.  2006 Dec;44(12):1464-1466.

A Case of Nicolau Syndrome Treated by Surgical Excision

Affiliations
  • 1Department of Dermatology, College of Medicine, Dong-A University, Busan, Korea. khkim@dau.ac.kr

Abstract

Nicolau syndrome or embolia cutis medicamentosa is an acute necrotic condition of skin that follows intramuscular injection of drugs. A 36-year-old man developed a painful, purpuric and erythematous patch on his left buttock following an intramuscular injection of diclofenac sodium. Histologically, the patch lesion displayed epidermal necrosis, dermal degeneration, and vascular thrombosis. We report a rare case of Nicolau syndrome following intramuscular injection of diclofenac sodium. In our case, the patient was successfully treated by surgical excision with primary closure.

Keyword

Diclofenac sodium; Embolia cutis medicamentosa; Nicolau syndrome

MeSH Terms

Adult
Buttocks
Diclofenac
Humans
Injections, Intramuscular
Necrosis
Skin
Thrombosis
Diclofenac
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