Korean J Dermatol.
2006 Nov;44(11):1380-1382.
A Case of Nicolau Syndrome
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- 1Department of Dermatology, Chonbuk National University Medical School, Jeonju, Korea. dermayun@chonbuk.ac.kr
Abstract
- Nicolau syndrome is a rare adverse reaction of the skin at the site of intramuscular drug injection, and has largely unidentified pathogenesis. It consists of the development of an acute, severe pain and a localized erythematous rash during intramuscular injection leading to cutaneous, subcutaneous and even muscular necrosis. We report a case of a 55-year-old woman who presented with a painful skin necrosis in her buttocks following an intramuscular diclofenac-beta-dimethyl-aminoethanol injection.
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