Korean J Dermatol.  2000 Jan;38(1):95-98.

Two Cases of Deep Vein Thrombosis Associated with Behcet's Disease

• Kim HS
• Chang SN
• Choi ES
• Oh D
• Park WH

Abstract

In Behcet's disease(BD), there is a marked increase in vascular complication. Venous thrombosis is a major feature of the disease, although arterial thrombosis is rarely described. In Behcet's disease, thrombosis occurs in 20 to 30% of patients. We present two cases of Behcet's disease admitted to our hospital whose chief complaint was progressive increases in swelling and pain in their legs. In the first case, routine coagulation tests and sero-immunological tests were within normal limits, however, protein C and S activity were significantly decreased in the patient. So these findings suggest that auto-immune acquired protein S deficiency may be involved in the pathogenesis of thrombotic events in BD.

Keyword

Behcet's disease; Deep vein thrombosis; Protein C and S

MeSH Terms

Humans
Leg
Protein C
Protein S Deficiency
Thrombosis
Venous Thrombosis*
Protein C