Allergic Contact Dermatitis due to Befunolol Hydrochloride in 0 . 5 % BentosR Eyedrops

Nam, Jong Taik; Kim, Ki Ho; Joh, Gwang Yeol

Abstract

Befunolol hydrochloride is a B-adrenergic receptor antagonist cornnory used topically in treatment of glaucoma because of a satisfactory intraocular pressure lowering apcity without relevant topical or systemic side effects. We repart herein a case of allergic contact dermatit.is due to befunc ol nydrochloride in 0.5% Bentos eyedrops, A 52-year-old Korean woman had suffered from erythemanedema with itching sensation on her left eye since Novembeir 18, 1992. She had used various ophtalrnic preparations including Bentos eyedrops containing befinolol hydrochloride 0,5% as its activ cinstituent since October, 1992 for treatment of glaucoma of her left eye. Patch test with the European standard series, rubber series, the patiants eyedrops and their individual constituents showed positive. reactions only to 0.5% Bentos eyedrops(as is) and to befunolol hydrochloride. We noted rapid improvement of skin lesions and syipsms after the withdrawal of Bentos eyedrops and applicatior of another B-blocker(carteolol hydrocilcide).