Korean J Hepatobiliary Pancreat Surg.  2012 May;16(2):65-69. 10.14701/kjhbps.2012.16.2.65.

Peripheral eosinophilia - is it a predictable factor associated with eosinophilic cholecystitis?

• Yeom SS
• Kim HH
• Kim JC
• Hur YH
• Koh YS
• Cho CK
• Kim HJ
• Shin SS
• Kim HS

• KMID: 2083325
• DOI: http://doi.org/10.14701/kjhbps.2012.16.2.65

Abstract

BACKGROUNDS/AIMS
The purpose of this study was to evaluate the role of peripheral eosinophilia as a predictable factor associated with Eosinophilic cholecystitis (EC) compared with other forms of cholecystitis in patients who underwent a cholecystectomy.
METHODS
Between January 2001 and May 2011, the histopathologic features of 3,539 cholecystectomy specimens were reviewed retrospectively. EC was diagnosed in 30 specimens (0.84%). Data from 30 consecutive patients with EC (eosinophilic cholecystitis group [E-group]) were compared with a retrospective control group of 60 patients (other cholecystitis group [O-group]) during the same period. The two groups were matched for age, gender, and the presence of cholelithiasis.
RESULTS
The median absolute eosinophil count 1 day post-operatively was 144 cells/mm3 (range: 9-801 cells/mm3) in the E-group and 93 cells/mm3 (range: 0-490 cells/mm3) in the O-group (p=0.036). Pre-operative peripheral eosinophilia was more common in the E-group than the O-group (20% vs. 3.3%, p=0.015). Multivariate analysis revealed that pre-operative peripheral eosinophilia was an independent significant predictable factor associated with EC (odds ratio=7.250, 1.365 <95% confidence interval<38.494, p=0.020).
CONCLUSIONS
In the present study, pre-operative peripheral eosinophilia was shown to be an independent predictable factor associated with EC. Further researches seem to be necessary to confirm this finding.

Keyword

Eosinophilic cholecystitis; Eosinophilia; Predictable factor; Cholecystectomy

MeSH Terms

Cholecystectomy
Cholecystitis
Eosinophilia
Eosinophils
Humans
Multivariate Analysis
Retrospective Studies

Figure

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  Fig. 1 Histopathology findings of eosinophilic cholecystitis. (A) Dense infiltration of eosinophils ([B] black arrow) involving the gallbladder diffusely in a transmural manner (>90%), suggesting eosinophilic cholecystitis (A: H&E stain, ×40, B: H&E stain, ×200).

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