Korean J Med.  2005 Dec;69(6):706-710.

Two different cases of episodic angioedema with eosinophilia

• Park CS
• Lee SS
• Lim JW
• An JM
• Lee TH
• Cho YS
• Moon HB

Abstract

Episodic angioedema with eosinophilia (Gleich's syndrome) is characterized by recurrent angioedema, fever, weight gain and peripneral eosinophilia. The symptoms and clinical course differ markedly from the idiopathic hypereosinophilic syndrome, including an absence of end organ involvement and a better prognosis. A transient variant, mainly reported in Japan, which is limited to a single attack, is usually less severe than the episodic type. Here we describe two young patients, one of those is the episodic type and the other is the transient type. We suggest that episodic angioedema with eosinophilia is not rare, and should be widely recognized as a new clinical entity for accurate and prompt diagnosis. Awareness and distinction from the hypereosinophilic syndrome is important because of the favorable prognosis and rapid response to corticosteroid therapy.

Keyword

Angioedema; Eosinophilia

MeSH Terms

Angioedema*
Diagnosis
Eosinophilia*
Fever
Humans
Hypereosinophilic Syndrome
Japan
Prognosis
Weight Gain