Korean J Nephrol.  2006 Jan;25(1):109-113.

Secondary Amyloidosis in Patient with Spinal Cord Injury: Renal and Thyroid Amyloidosis

• Han ST
• Kim MS
• Yu JM
• Yea CJ
• Byun JW
• Han BG
• Choi SO

Abstract

Amyloidosis is an acquired or inherited disorder with protein folding and degradation characterizing the deposition of the proteinaceous material in the extracellular matrix of one or several organs. Secondary amyloidosis resulting from the deposition of serum amyloid A protein, occurs 1-5% during the lifetime of patients with chronic inflammatory disorders such as rheumatoid arthritis and ankylosing spondylitis. In addition, chronic pyelonephritis and pressure sores in patient with spinal cord injury are documented as risk factors of secondary amyloidosis. Thus, the efforts to treat and prevent the development of secondary amyloidosis and to preserve the renal function should focus on avoiding the chronic inflammatory state and a pathologic study of doubtful organs for early diagnosis should be performed. We have experienced one case of secondary amyloidosis in patient with spinal cord injury which involves with kidney and thyroid gland.

Keyword

Amyloidosis; Spinal cord injury

MeSH Terms

Amyloidosis*
Arthritis, Rheumatoid
Early Diagnosis
Extracellular Matrix
Humans
Kidney
Pressure Ulcer
Protein Folding
Pyelonephritis
Risk Factors
Serum Amyloid A Protein
Spinal Cord Injuries*
Spinal Cord*
Spondylitis, Ankylosing
Thyroid Gland*
Serum Amyloid A Protein