Korean J Nephrol.  2005 Mar;24(2):170-180.

The Expressions of PDGF-C, PDGF-D and PDGF Receptors in Renal Development Model

• Moon SO
• Cho ES
• La BJ
• Kang KP
• Lee S
• Sung MJ
• Kang SK
• Park SK
• Kim W

Abstract

BACKGROUND
Four platelet derived growth factor (PDGF) family members have been identified; the classical PDGFs, PDGF-A and PDGF-B, and the novel PDGFs, PDGF-C and PDGF-D, which were only recently discovered. METHODS: The present study was designed to determine the changes of the platelet derived growth factor (PDGF) subtypes (C & D) and their receptors (PDGFR)-alpha & beta expression in kidneys during pre- and postnatal development. RESULTS: All the protein levels of PDGFR-alpha and -beta and the mRNA levels of PDGF-C and D were high in kidneys during the prenatal period and decreased differently during the postnatal period. PDGFR-alpha was expressed in the interstitial space at embryo day 18. PDGFR-beta protein were expressed in metanephric blastema at embryo day 18. PDGF-C mRNA was expressed in metanephric blastema, developing glomerulus at embryo 18 day and in collecting duct at postnatal day 7. PDGF-D mRNA was expressed in the parietal and vesceral epithelial cells during pre and postnatal period. CONCLUSION: These results indicate that the PDGF subtypes (C & D) and their receptors (PDGFR-alpha & -beta) are differently expressed in the kidney during the prenatal and postnatal period.

Keyword

PDGF-C; PDGF-D; Kidney; Development

MeSH Terms

Embryonic Structures
Epithelial Cells
Humans
Kidney
Platelet-Derived Growth Factor
Rabeprazole
Receptors, Platelet-Derived Growth Factor*
RNA, Messenger
Platelet-Derived Growth Factor
RNA, Messenger
Receptors, Platelet-Derived Growth Factor