Korean J Obstet Gynecol.  2002 Nov;45(11):1991-1995.

A Comparison of Efficacy and Safety of Ritodrine hydrochloride alone and Combined Treatment with Magnesium sulfate in the Management of Preterm Labor

• Kim YA
• Kang HS
• Yang SH
• Kim JH

Abstract

OBJECTIVE
This study was designed to compare the efficacy and safety of the ritodrine hydrochloride alone with combined treatment with magnesium sulfate in the management of preterm labor.
METHODS
One hundred thirty three singleton pregnancies with preterm labor were treated with either ritodrine hydrochloride (n=97) or ritodrine hydrochloride and magnesium sulfate (n=36). The principal outcomes assessed were delay of duration, maternal-fetal side effects, and fetal outcome.
RESULTS
The treatment to delivery time was not statistically different between the ritodrine group and the combined magnesium sulfate group (mean+/-SD 10.7+/-13.0 days, 8.6+/-9.1 days, respectively). The proportion delivered after 48 hours, 72 hours, or 7 days was also not statistically different between two groups (29% vs. 22%, 40% vs. 39%, 60% vs. 64%, respectively). No statistical difference was found in the side effects of treatment or fetal outcomes.
CONCLUSION
There was no significant difference in efficacy and safety between ritodrine hydrochloride and combined treatment with magnesium sulfate in the management of preterm labor.

Keyword

ritodrine hydrochloride; magnesium sulfate; preterm labor

MeSH Terms

Female
Magnesium Sulfate*
Magnesium*
Obstetric Labor, Premature*
Pregnancy
Ritodrine*
Magnesium
Magnesium Sulfate
Ritodrine