Korean J Obstet Gynecol.  2001 Apr;44(4):668-673.

Insulin-like growth factor-I and II and insulin-like growth factor binding protein-3 in amniotic fluid at second trimester: A correlation with birth weight

• Kim JY
• Yang SH
• Lee IS

Abstract

OBJECTIVE
o determine the correlation between birth weight and the level of insulin-like growth factor(IGF)-I, -II and insulin-like growth factor binding protein(IGFBP)-3 in amniotic fluid at second trimester and to evaluate possibility whether the levels of IGF-I, II and IGFBP-3 could predict birth weight.
METHODS
Sixty-seven samples of amniotic fluid in second trimester were analyzed for IGF-I, IGF-II, and IGFBP-3 by radioimmunoassay. Newborn birth weights were stratified arbitrarily as <25th percentile, 25-75th percentile, and >75th percentile. Linear regression analysis and Kruskal-Wallis test were used in well appropriately for statistical analysis.
RESULTS
The level of IGF-I showed positive correlation with birth weight. However, the levels of IGF-II and IGFBP-3 showed no significant correlation with birth weight. The level of IGF-I were signifi cantly different among these groups. However, the levels of IGF-II and IGFBP-3 were not significantly different among these groups divided by the birth weight percentile.
CONCLUSION
The levels of IGF-I in amniotic fluid at second trimester may be useful marker in predicting birth weight.

Keyword

Insulin-like growth factor; Insulin-like growth factor binding protein; Amniotic fluid; Birth weight

MeSH Terms

Amniotic Fluid*
Birth Weight*
Female
Humans
Infant, Newborn
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II
Linear Models
Parturition*
Pregnancy
Pregnancy Trimester, Second*
Radioimmunoassay
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II