Korean J Otorhinolaryngol-Head Neck Surg.  2009 Jul;52(7):594-598. 10.3342/kjorl-hns.2009.52.7.594.

Immunoglobulin E and Transcription Factor in Adenoid of Children with Allergy

Affiliations
  • 1Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Sungkyunkwan University, Masan Samsung Hospital, Masan, Korea.
  • 2Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Kyung Hee University, Seoul, Korea. yeo2park@yahoo.com

Abstract

BACKGROUND AND OBJECTIVES
Immunoglobulin E (IgE) production in adenoid has been debated and the role of adenoid in development of allergy remains largely unknown. To examine the production of local IgE in adenoid involved with IgE-mediated sensitization, we evaluated IgE production and the expression of the transcription factor B cell leukemia/lymphoma-6 (BCL-6) and B lymphocyte inducer of maturation program 1 (Blimp-1) in adenoids. SUBJECTS AND METHOD: Ten children with allergic rhinitis (AR) and ten children without any history of AR were enrolled. Immunohistochemical studies of adenoid for IgE, BCL-6 and Blimp-1 were performed.
RESULTS
IgE was stained mainly in the germinal center and submucosal area and the stainingscores of antibody to IgE did not differ signigicantly between children with AR and control. BCL- 6 was mainly stained in mucosa and germinal center and Blimp-1 in mucosa. The scores of antibody to BCL-6 and Blimp-1 in children with AR and control did not show significant differences.
CONCLUSION
We found that allergic rhinitis was not involved in the production of IgE nor the expression of the transcription factor BCL-6 and Blimp-1 in adenoid

Keyword

Adenoid; IgE; BCL-6; Blimp-1; Allergy
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