Korean J Pediatr.
2007 May;50(5):493-496. 10.3345/kjp.2007.50.5.493.
A case of dapsone syndrome
- Affiliations
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- 1Department of Pediatrics, School of Medicine, Wonkwang University, Iksan, Korea. cdy8118@wonkwang.ac.kr
- KMID: 2072888
- DOI: http://doi.org/10.3345/kjp.2007.50.5.493
Abstract
- Diamino-diphenyl-sulfone (Dapsone) is widely used in the treatment of leprosy and a variety of blistering skin diseases. It sometimes has adverse side effects with common usual doses, such as skin, nervous system, gastrointestinal tract, liver, kidney and hematologic toxicity. One of these side effects is a rare but serious hypersensitivity reaction called dapsone syndrome, which occurs several weeks after the initial administration of the drug and results in unpredictable, sometimes fatal outcomes. This report deals with a 13-year-old girl's case with typical features of dapsone syndrome that included fever, exfoliative dermatitis, jaundice, hemolytic anemia and pleural effusion after being treated with dapsone for four weeks.
