Plasma Fibronectin Levels in Preeclampsia

Lee, Jeung Hyung; Kim, Hyun Chan

Abstract

Current concept of the pathogenesis of preeclampsia involves the generalized dysfunction of maternal vascular endothelial cells. Using ELISA (enzyme-linked immunosorbent assay) method, the fibronectin, as a marker of endothelial cell injury, was measured in the group of 35 cases of preeclampsia (mild; 15 and severe; 20 cases) and the control group of 21 cases of normal pregnancy. The clinical profiles, hematologic and renal function test results were compared and correlated with the levels of plasma fibronectin between two groups. The results obtained were as follows 1. The mean age between preeclampsia and control group was not different statistically, but gestational age, birth weight and maternal weight were different significantly between two groups. 2. Compared with normal control group, plasma levels of fibronectin were signifi- cantly elevated in preeclampsia group. As to the differential validity between two groups (control vs preeclampsia), using cutoff value of 380 mg/dl, sensitivity was 95.7 %, specificity was 90.5 %, predictive value was 93.8 %. As to the differential validity between mild and severe preeclampsia, using cutoff value of 742 mg/dl, sensitivity was 65.0 %, specificity was 73.3 %, predictive value was 76.5%. 3. As to the correlationship between plasma fibronectin levels and hematologic test results, uric acid and creatinine levels showed positive correlation in preeclampsia. Based upon these study results, plasma fibronectin could be a useful parameter for the differential diagnostic validity and grade of preeclampsia.