J Korean Assoc Oral Maxillofac Surg.  2015 Oct;41(5):273-277. 10.5125/jkaoms.2015.41.5.273.

Primary oral soft tissue angiosarcoma of the cheek: a case report and literature review

• Fomete B
• Samaila M
• Edaigbini
• Agbara R
• Okeke UA

• KMID: 2070443
• DOI: http://doi.org/10.5125/jkaoms.2015.41.5.273

Abstract

Angiosarcoma is a rare and aggressive malignant tumor that has a poor prognosis. It represents less than 1% of all malignancies occurring in the oral cavity and salivary glands. We present a 35-year-old male with angiosarcoma of the cheek following traumatic injury and a review of the current literature.

Keyword

Primary; Angiosarcoma; Cheek; Oral; Soft tissue

MeSH Terms

Adult
Cheek*
Hemangiosarcoma*
Humans
Male
Mouth
Prognosis
Salivary Glands

Figure

• 

  Fig. 1 Patient lesion prior to surgery.

• 

  Fig. 2 Computed tomography angiogram.

• 

  Fig. 3 Isolation of major vessels.

• 

  Fig. 4 Excised specimen cut open.

• 

  Fig. 5 A. Intraluminal buds of tumor cells (H&E staining, ×40). B. Sheets of epitheliod tumour cells (H&E staining, ×40). C. Strong positivity with highlights of neoplastic vascular channels (CD31 staining, ×40).

Reference

1. Ramadhan A, Willén H, Thor A. Angiosarcoma of the mandible: metastasis from a primary tumour of the right atrium of the heart. Case Rep Clin Med. 2013; 2:53–57.

2. Köhler HF, Neves RI, Brechtbühl ER, Mattos Granja NV, Ikeda MK, Kowalski LP. Cutaneous angiosarcoma of the head and neck: report of 23 cases from a single institution. Otolaryngol Head Neck Surg. 2008; 139:519–524. PMID: 18922337.

3. Yang XJ, Zheng JW, Zhou Q, Ye WM, Wang YA, Zhu HG, et al. Angiosarcomas of the head and neck: a clinico-immunohistochemical study of 8 consecutive patients. Int J Oral Maxillofac Surg. 2010; 39:568–572. PMID: 20413272.

4. Nagata M, Yoshitake Y, Nakayama H, Yoshida R, Kawahara K, Nakagawa Y, et al. Angiosarcoma of the oral cavity: a clinicopathological study and a review of the literature. Int J Oral Maxillofac Surg. 2014; 43:917–923. PMID: 24656496.

5. Lydiatt WM, Shaha AR, Shah JP. Angiosarcoma of the head and neck. Am J Surg. 1994; 168:451–454. PMID: 7977971.

6. Terada T. Angiosarcoma of the mandibular gingiva. Int J Clin Exp Pathol. 2011; 4:791–793. PMID: 22135727.

7. Sarachev E, Mateeva G. Angiosarcoma of the oral cavity. Int Med Assoc Bulgaria. 2006; 12:33–34.

8. Fanburg-Smith JC, Furlong MA, Childers EL. Oral and salivary gland angiosarcoma: a clinicopathologic study of 29 cases. Mod Pathol. 2003; 16:263–271. PMID: 12640107.

9. Trinh NQ, Rashed I, Hutchens KA, Go A, Melian E, Tung R. Unusual clinical presentation of cutaneous angiosarcoma masquerading as eczema: a case report and review of the literature. Case Rep Dermatol Med. 2013; DOI: 10.1155/2013/906426.

10. Sumida T, Murase R, Fujita Y, Ishikawa A, Hamakawa H. Epulis-like gingival angiosarcoma of the mandible: a case report. Int J Clin Exp Pathol. 2012; 5:830–833. PMID: 23074540.

11. Chadha V, Rawat DS, Prasad B. Primary angiosarcoma of the tongue: a case report. Int J Otolar Head Neck Surg. 2012; 1:51–52.