J Korean Neurosurg Soc.  1995 Jun;24(6):623-630.

Study on Contractile Responses Induced by Anoxia in Porcine Cerebral Artery

• Ko JS
• Kang SS
• Baik YH

Abstract

This study was designed to observe anoxia-induced responses and to clarify their possible mechanisms in porcine basilar and circle of Willis arteries. Anoxia produced a transient vasoconstriction, which then recovered to the basal tension of a 3-5 min. later, and the reoxygenation that follows produced the biphasic(relaxation-contraction) response in the intact endothelial rings under resting tension. The anoxia-induced contraction was potentiated by pretreatment with KC1 and PGF2alpha. Reoxygenation produced only sustained relaxation. Removal of the endothelium and pretreatment with nimodipine or indomethacine markedly attenuated the anoxia-induced contractions. Anoxia transiently and significantly increased cyclic GMP contents in the endothelium-intact preparations, but did not affect them in the endothelium-removed ones. The above results suggest that anoxia-induced contraction is endothelium-dependent and is resultant to the release of a Prostaglandin-like substance(s) .

Keyword

Anoxia; Porcine cerebral arteries; Endothelium; Endothelium; Cyclic GMP; Prostaglandin

MeSH Terms

Anoxia*
Arteries
Cerebral Arteries*
Circle of Willis
Cyclic GMP
Dinoprost
Endothelium
Indomethacin
Nimodipine
Relaxation
Vasoconstriction
Cyclic GMP
Dinoprost
Indomethacin
Nimodipine