J Korean Neurosurg Soc.  1999 Aug;28(8):1208-1214.

Pathogenesis of Cerebral Vasospasm

• Moon CT

Abstract

Although cerebral vasospasm is the greatest cause of morbidity and mortality in patient who survive the ictus of subarachnoid hemorrhage(SAH), the pathogenesis of vasospasm remains unclear. However, recent advances in the research of vasospasm suggest that decreased vasodilator function and/or increased vasoconstrictor function are basic changes of cerebral vasculature after SAH. So, the present review will focus on the roles of nitric oxide(NO), cGMP, potassium channel, endothelin(ET), and protein kinase C(PKC) as they relate to SAH.

Keyword

Cerebral vasospasm; Subarachnoid hemorrhage; Nitric oxide; cGMP; Potassium channel; Endothelin; Protein kinase C

MeSH Terms

Endothelins
Humans
Mortality
Nitric Oxide
Potassium Channels
Protein Kinase C
Protein Kinases
Subarachnoid Hemorrhage
Vasospasm, Intracranial*
Endothelins
Nitric Oxide
Potassium Channels
Protein Kinase C
Protein Kinases