Korean J Thorac Cardiovasc Surg.
1997 Nov;30(11):1136-1138.
Cyclosporine-Associated Central Neurotoxicity after Hearat Transplantation: 1 Case Report
- Affiliations
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- 1Department of Thoracic and Cardiovascular Surgery, College of Medicine, University of Ulsan, Asan Medical Center, Korea.
Abstract
- A 45-year-old man underwent heart transplantation due to dilated cardiomyopathy. Cyclosporine, 2 mg/kg per day, was intravenously given postoperatively. As central neurotoxicity signs that were included pin-point pupil, no light reflex, coma, were presented at 8 postoperative hours, cyclosporine was decreased to 1 mg/kg per day. At that time the cyclosporine level was 345 micro gram/L, the serum creatinine level was 1.8mg/dl and the serum magnesium level was within normal limit. He awaked at 31 postoperative hours and all sign of cyclosporine-induced central neurotoxicity was resolved after postoperative days. He was discharged without sequale at postoperative day 28.
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