Characteristics of Multiple Primary Malignant Neoplasms Associated with the Urinary Tract Malignancy

Lee, Joong Shik; Kim, Jang Hwan; Choi, Young Deuk

Abstract

PURPOSE: Improvement in the prognosis of multiple primary malignant neoplasm may be attained by early discovery and awareness of the secondary tumor. This study aimed to determine the characteristics of multiple primary neoplasms involving the urinary tract in Korea.
MATERIALS AND METHODS
Of 1,406 patients treated for urologic cancers, 76 patients with multiple primary neoplasms also involving other than the genitourinary system were analyzed. We studied the occurrence rate and distribution of tumors.
RESULTS
Of the 76 cases, 33 cases were synchronous and 43 cases were metachronous. Average time interval between the diagnosis of first and second tumor was 48 months. Tumors of the gastrointestinal tract, particularly stomach cancer, among non-urologic cancers and tumors of the bladder among urologic cancers were predominantly involved followed by renal and prostate tumors. However, renal tumor was the most common urologic tumor in synchronous cancers. Eighty-one percent of the metachronous urinary tumors occurred as second tumors.
CONCLUSIONS
Our present findings show that the occurrence of multiple primary neoplasms involving the urinary tract is not rare and that the incidence of organ involvement is different from the western countries.