Neonatal Med.  2015 Feb;22(1):51-54. 10.5385/nm.2015.22.1.51.

A Novel MUT Gene Mutation Detected in a Female Infant with Methylmalonic Acidemia

  • 1Department of Pediatrics, Daegu Fatima hospital, Daegu, Korea.
  • 2Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.


Methylmalonic acidemia (MMA) is an autosomal recessive metabolic disease. MMA results from a deficiency of L-methylmalonyl-CoA mutase (encoded by MUT), its cofactor 5-deoxyadenosylcobalamin (MMAA, MMAB, and MMADHC), or a deficiency of methylmalonyl CoA-epimerase (MCEE). We report the case of a 5-day-old infant with MMA in which a missense and a novel nonsense mutation in MUT were present. Direct sequencing analysis of MUT revealed a heterozygous c.1106G>A (p.Arg369His) mutation in exon 6 and a heterozygous c.362_368dupAGTTCTA (p.Tyr123*) mutation in exon 2; the latter results in a premature stop codon.


Methylmalonic acidemia; L-methylmalonyl-CoA mutase; Nonsense mutation
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