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Dose-Response Association between Smoking Cessation and Arterial Stiffness: The Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) Cohort

Lee GB, Shim JS, Kim HC

BACKGROUND AND OBJECTIVES: Cigarette smoking has been reported to be associated with arterial stiffness. However, the clinical relevance of smoking cessation on arterial stiffness is debatable. Thus, we evaluated whether...
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Can Calprotectin Show Subclinical Inflammation in Familial Mediterranean Fever Patients?

Asan G, Derin ME, DoÄŸan HO, Bayram M, Åžahin M, Åžahin A

BACKGROUND: Familial Mediterranean fever (FMF) is an autoinflammatory disease that has self-limiting inflammatory attacks during polyserositis. Hepcidin is a protein, and interleukin-6 stimulation increases hepcidin levels. Calprotectin (CLP) is a...
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Impact of Skeletal Muscle Mass on Metabolic Health

Kim G, Kim JH

Skeletal muscle is regarded as an endocrine and paracrine organ. Muscle-derived secretory proteins, referred to as myokines, mediate interactions between skeletal muscle mass and other organs such as the liver,...
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Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women

Wang Y, Zhu J, Aroner S, Overvad K, Cai T, Yang M, Tjønneland A, Handberg A, Jensen MK

BACKGROUND: Membrane CD36 is a fatty acid transporter implicated in the pathogenesis of metabolic disease. We aimed to evaluate the association between plasma CD36 levels and diabetes risk and to...
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Relationship between the Distribution of Comorbidity and Length of Stay and Medical Cost for Planning Integrated Community Care Services among Inpatients at a Seoul Municipal Hospital

Kim JH, Noh JW, Lee Y, So Y, Hong H

BACKGROUND: This study is to investigate the association between the distribution of multimorbidity and length of stay and medical expenses among inpatients in a municipal hospital to achieve an integrated...
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Effect of Diet on the Gut Microbiota Associated with Obesity

Kim B, Choi HN, Yim JE

Obesity is abnormal or excessive fat accumulation that is associated with progression of metabolic diseases including type 2 diabetes mellitus, cardiovascular disease, nonalcoholic fatty liver disease, and cancer. Gut microbiota...
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Chronic oral administration of Passiflora incarnata extract has no abnormal effects on metabolic and behavioral parameters in mice, except to induce sleep

Kim GH, Yi SS

Although the number of prescriptions and dependence on sleeping pills are increasing, the associations with unexpected abnormal behaviors and metabolic diseases caused by the overuse of sleeping pills are not...
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High fiber and high carbohydrate intake and its association with the metabolic disease using the data of KNHANES 2013 ~ 2017

Moon H, Ha K, Song Y

PURPOSE: Dietary fiber is a component of carbohydrate that is linked closely with the carbohydrate quality, but few studies have investigated the association of high fiber intake with the cardiometabolic...
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Early Assessment of the Risk for Gestational Diabetes Mellitus: Can Fasting Parameters of Glucose Metabolism Contribute to Risk Prediction?

Falcone V, Kotzaeridi G, Breil MH, Rosicky I, Stopp T, Yerlikaya-Schatten G, Feichtinger M, Eppel W, Husslein P, Tura A, Göbl CS

BACKGROUND: An early identification of the risk groups might be beneficial in reducing morbidities in patients with gestational diabetes mellitus (GDM). Therefore, this study aimed to assess the biochemical predictors...
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Propionic Acidemia with Novel Mutation Presenting as Recurrent Pancreatitis in a Child

Choe JY, Jang KM, Min SY, Hwang SK, Kang B, Choe BH

Propionic acidemia (PA) is a rare organic acidemia resulting from a deficiency of the mitochondrial enzyme propionyl-coenzyme A carboxylase. Most cases are diagnosed after the detection of metabolic abnormalities—such as...
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Implementation of a Targeted Next-Generation Sequencing Panel for Constitutional Newborn Screening in High-Risk Neonates

Lee H, Lim J, Shin JE, Eun HS, Park MS, Park KI, Namgung R, Lee JS

PURPOSE: Newborn screening (NBS) programs are important for appropriate management of susceptible neonates to prevent serious clinical problems. Neonates admitted to neonatal intensive care units (NICU) are at a potentially...
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The Role of the Gut Microbiota in Obesity

Kim H, Baeg MK, Kim JH, Diet, Obesity, and Metabolism Research Group of Korean Society of Neurogastroenterology and Motility

Obesity is a critical target for public health interventions worldwide. There are many causes of obesity, and the importance of the gut microbiota in its pathogenesis has recently been recognized....
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Regulation of Systemic Glucose Homeostasis by T Helper Type 2 Cytokines

Kang YE, Kim HJ, Shong M

Obesity results in an inflammatory microenvironment in adipose tissue, leading to the deterioration of tissue protective mechanisms. Although recent studies suggested the importance of type 2 immunity in an anti-inflammatory...
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Prognostic value of post-treatment ¹⁸F-fluorodeoxyglucose positron emission tomography in uterine cervical cancer patients treated with radiotherapy: a systematic review and meta-analysis

Kim YJ, Han S, Kim YS, Nam JH

OBJECTIVES: To perform a systematic review and meta-analysis of the prognostic value of post-treatment 18F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG PET) in uterine cervical cancer patients treated with radiotherapy (RT) with...
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Increased Serum Angiopoietin-Like 6 Ahead of Metabolic Syndrome in a Prospective Cohort Study

Namkung J, Sohn JH, Chang JS, Park SW, Kim JY, Koh SB, Kong ID, Park KS

BACKGROUND: Despite being an anti-obesity hepatokine, the levels of serum angiopoietin-like 6 (ANGPTL6) are elevated in various metabolic diseases. Thus, ANGPTL6 expression may reflect metabolic burden and may have compensatory...
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Cohort Profile: The Cardiovascular and Metabolic Diseases Etiology Research Center Cohort in Korea

Shim JS, Song BM, Lee JH, Lee SW, Park JH, Choi DP, Lee MH, Ha KH, Kim DJ, Park S, Lee WW, Youm Y, Shin EC, Kim HC

Mortalities from cardiovascular disease in Korea have decreased markedly over the past three decades. The major cardiovascular and metabolic risk factors, however, remain prevalent, and their burden on health is...
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Components of Metabolic Syndrome in Korean Adults: A Hospital-Based Cohort at Seoul National University Bundang Hospital

Lim S, Min SH, Lee JH, Kim LK, Lee DH, Lee JE, Kim KM, Lee S, Park KC, Lee YJ

BACKGROUND: The prevalence of metabolic syndrome is increasing in Korea, particularly among young adults. This trend will increase the incidence of cardiovascular and metabolic diseases in the future. Therefore, it...
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The Role of Gut Microbiota and Use of Probiotics in the Treatment of Upper Gastrointestinal Diseases

Lee MY, Choi SC, Kim YS

Gut microbiota have been known to play an essential role in host immunity and metabolism. Dysbiosis is associated with various gastrointestinal (GI) and other diseases such as cancers, metabolic diseases,...
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Free fatty acid-induced histone acetyltransferase activity accelerates lipid accumulation in HepG2 cells

Chung S, Hwang JT, Park JH, Choi HK

BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a common metabolic disease triggered by epigenetic alterations, including lysine acetylation at histone or non-histone proteins, affecting the stability or transcription of lipogenic...
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Simultaneous Analysis of Four Standards of The Herbal Formula, DF-02, of Ephedra intermedia and Rheum palmatum, using by High Performance Liquid Chromatography-Ultraviolet Detector (HPLC-UVD)

Choi SY, Jeong B, Jang HS, Lee J, Kwon YS, Yoon Y, Shin SS, Yang H

The herbal formula, DF-02, consisting of Ephedra intermedia and Rheum palmatum are used for the treatment of the metabolic diseases such as obesity and liver fibrosis in Korean local clinics....
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