Clin Pediatr Hematol Oncol.  2013 Apr;20(1):75-78.

Growing Teratoma Syndrome of the Pineal Gland Recognized Very Early during Chemotherapy in a Child with a Non-Germinomatous Germ-Cell Tumor

  • 1Department of Pediatrics, Chonnam National University Hwasun Hospital, Hwasun-gun, Korea.
  • 2Department of Pediatrics, Shenzen People's Hospital, China.
  • 3Department of Neurosurgery, Chonnam National University Hwasun Hospital, Hwasun-gun, Korea.
  • 4Department of Pathology, Chonnam National University Medical School, Gwangju, Korea.


The growing teratoma syndrome (GTS) is defined as the development of mature low-grade elements in the absence of a recurrent non-germinomatous germ-cell tumor (NGGCT) after partial response to multimodal treatment. It is uncommon and may occur in intracranial NGGCTs. Here, we report that a 7-year-old boy with intracranial NGGCT presented with precocious puberty and developed growing teratoma syndrome only 2 weeks after the first cycle of chemotherapy.


Growing teratoma syndrome; Non-germinomatous germ cell tumors; Immature teratoma
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